Comm Eye Health Vol. 33 No. 109 2020 pp 22-27. Published online 09 July 2020.

Personal protective equipment for COVID-19 in eye care

Elanor Watts

Doctor and MSc Student: International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK.


Astrid Leck

Research Fellow and microbiologist: London School of Hygiene & Tropical Medicine, London, UK.


Victor Hu

Assistant Clinical Professor: International Centre for Eye Health, London School of Hygiene & Tropical Medicine & Consultant Ophthalmologist, Mid Cheshire NHS Hospitals, UK.


A health care worker wearing a blue gowns, blue surgical caps, surgical mask and gloves helping a colleague to fasten the back of their gown
Two health care workers help each other to safely put on PPE. UGANDA © Gilbert Arinda
Related content

The main role of personal protective equipment (PPE) within health care settings is to reduce the potential risk of transfer of infectious microorganisms between health care workers and patients. During the pandemic, this is more important than ever.

Personal protective equipment (PPE) such as gloves, aprons, long-sleeved gowns, eye goggles, face shields (or visors), surgical masks and respirator masks protect health workers and patients. PPE interrupts the chain of infection (Figure 1) by blocking the portals of exit and the portals of entry. This reduces the risk of health workers transmitting the SARS-CoV-2 virus to others, or becoming infected with the SARS-CoV-2 virus themselves.

A diagram of the chain of infection with specific details for each link in the chain
Figure 1 The chain of infection as it applies to COVID-19.

Viral transmission

The SARS-CoV-2 virus, responsible for COVID-19, is usually transmitted via small respiratory droplets, produced when an infected person coughs, sneezes, speaks or exhales.1 These droplets (bigger than 5 μm in diameter) contain viable viral particles and generally fall from the air within 1 metre of the contagious person.

Droplet transmission takes place when the droplets make direct contact with the conjunctiva of the eyes, or the mucous membranes of the nose and mouth of another person.

Contact transmission takes place when someone touches their eyes, nose, or mouth with contaminated hands, e.g., after touching surfaces such as mobile phones, door handles or slit lamps that have already been contaminated by virus-containing droplets (or touched by someone else with contaminated hands). SARS-CoV-2 can survive on smooth surfaces for several days, but is susceptible to standard disinfectant methods.2

Airborne transmission involves very small droplet particles which can remain in the air for much longer and travel further than droplets before being inhaled.1 These particles (or droplet nuclei) are less than 5 μm in diameter and can be produced during aerosol-generating procedures (AGPs) such as endotracheal intubation, upper ENT airway procedures involving suctioning, and non-invasive ventilation (e.g. continuous positive airway pressure).

This poses a greater risk to health care workers, so higher levels of PPE are needed, such as a filtering face-piece respirator (e.g., N95 or FFP2 masks) and a fluid-resistant gown. AGPs should also be prioritised when allocating PPE.

There is considerable debate as to whether airborne transmission plays a role in the spread of COVID-19 outside of settings where AGPs are performed. The World Health Organization (WHO) is currently evaluating the role of airborne transmission, and recently said that it “cannot be ruled out” in settings that are crowded, closed and poorly ventilated (see bit.ly/WHOairbornevideo). Visit www.who.int for the latest updates and guidelines.

Ophthalmic surgery: which procedures pose a risk of SARS-CoV-2 transmission?

The SARS-CoV-2 virus can be present in the tear film3; however, the relevance of this regarding infection transmission is not yet known. The use of preoperative povidone-iodine as part of standard surgical preparation should inactivate any virus present in the tear film or on the ocular surface.4 At present, there is no evidence for the presence of virus in the aqueous or vitreous, but the presence of intraocular virus is theoretically possible.

For phacoemulsification, aerosolisation may occur at the wound edge. However, the aqueous will have been replaced by viscoelastic, and then saline, by the time this happens, so it is unlikely that any aqueous will be present during actual phacoemulsification. Operations such as small-incision and extra-capsular cataract surgery should be low risk. The use of cautery could lead to aerosolisation of virus on the ocular surface; it should be used sparingly, followed by irrigation with saline. The PPE recommended for “Theatres where AGPs not done” in Table 1 should be adequate for such surgery.

Many oculoplastic procedures, especially if involving entry into the nasal cavity or lacrimal drainage system, should be considered high-risk, as should surgery involving general anaesthesia. The PPE recommended for “Performing an aerosol generating procedure (AGP)” in Table 1 should be used.

For up-to-date guidance on the risks of transmission during these and other ophthalmic procedures, refer to the American Academy of Ophthalmology (AAO) guidance5 available here: bit.ly/AAOrisk.

The use of masks by patients is becoming more widespread in reducing the risk of transmission during a hospital visit.6–8 However, there are concerns that a mask may direct the patient’s exhaled breath up and into the surgical field during ophthalmic procedures, which carries a risk of contamination. The mask can also get in the way of cleaning the surgical area and the procedure itself. Once the surgical drape has been properly positioned, it may therefore be advisable to lower the patient mask until surgery is completed.

What PPE should we use?

Transmission of SARS-CoV-2 can be minimised by:

  • Cleaning and disinfecting equipment and surfaces to prevent cross-contamination and spread.
  • Washing hands.
  • Protecting the eyes,4 mouth, nose and clothes by wearing PPE according to national, local or hospital guidelines.
An example of a poster with cartoon graphics
Figure 2 Posters can provide useful reminders about the personal protective equipment (PPE) needed for different activities. Note: heavy-duty gloves must be decontaminated or changed between clinical environments, else they can be a source of contamination. Source: bit.ly/PPEposter

The American Academy of Ophthalmology (AAO) has produced guidance on the risks during eye surgery5 (see panel) and the Royal College of Ophthalmologists, UK, has produced guidance on the type of PPE recommended in different situations,9 depending on risk (Table 1). Visit bit.ly/RCOpth for up-to-date guidance.

Image of a table detailing recommended PPE for different clinical activities
Table 1 Recommended PPE, as per UK Royal College of Ophthalmologists Guidelines

In low-risk situations, where there is a risk of droplet and contact transmission only, the advice is to wear disposable gloves, eye protection (goggles or a face shield), a disposable plastic apron and a surgical mask.

In high-risk situations (where there is a risk of airborne transmission), the advice is to wear disposable gloves, eye protection, a disposable fluidresistant gown and a filtering face-piece respirator (N95, FFP2 or FFP3 masks).

Non-clinical personnel

It is important to recognise that everyone in the health care setting is at potential risk of exposure to SARS-CoV-2, including receptionists, cleaners, pharmacists, administrators, patients and the people who accompany them. Guidelines must be available for all these groups, which includes recommending appropriate PPE and encouraging good hand hygiene.

For example, cleaners should be given full PPE (mask, eye protection, gloves, gown and closed work shoes) and personnel carrying out screening and triage can be protected by enforcing distancing of at least 1 metre between them and others, and by providing a glass or plastic screen as a barrier.

The World Health Organisation (WHO) provides excellent guidance on PPE for everyone working in the health care setting. bit.ly/PPEguideCOV19

Face masks

Never wear a mask just over your mouth and not your nose, as this exposes the mucous membranes of the nose and puts you at risk of inhaling virus-containing droplets.

Different types of face masks are available, with varying levels of protection:

  • Fabric masks are home-made masks, bandanas or scarves which cover the nose and mouth. The level of protection they offer the wearer is uncertain, and depends on the fabric and the fit.11 The purpose of fabric masks is to prevent the wearer from spreading viral particles to others when coughing, sneezing, talking or breathing out, particularly on public transport. Wash fabric masks after each use to prevent them from acting as a fomite: a contaminated surface or object that can spread the virus to others.
  • Surgical masks should be fluid-resistant to splash or spray of bodily fluids. This type of mask provides some protection against droplet transmission, but the wearer can still breathe unfiltered air around the edge of the mask. The main role of these, and fabric masks, is to reduce transmission of infectious droplets from the wearer to other people. They are suitable for areas with a low risk of exposure.
  • Filtering face piece (FFP) respirators. These form a tight seal around the edge of the mask so all air passes through the filter. This type of mask is designed to protect the wearer and the people they come into contact with from infectious droplets. FFP2 or N95 masks (European and US terminology respectively) filter at least 94–95% of particles bigger than 0.3 μm in diameter. FFP3 or N99 masks filter at least 99% of particles bigger than 0.3 μm. These both meet the WHO criteria for SARS-CoV-2 and can be used in high-risk settings and procedures. The only reliable way to distinguish between different FFP masks is to read what is printed on them. FFP1 masks are not sufficient to protect against COVID-19.

Some countries are recommending that patients wear either surgical masks or fabric masks during their clinic visits and/or when outside their home.6–8

Poster depicting how to put on, wear and remove a medical face mask
Figure 4 World Health Organization guidance on how to wear a mask safely. © WHO
Poster depicting the incorrect way to put on, wear and remove a medical face mask
Figure 4 World Health Organization guidance on how to wear a mask safely. © WHO

Exactly when masks are changed will depend on local shift patterns, the frequency of breaks, and PPE supply. FFP respirators can normally only be worn for a relatively short period as the filter fills up after prolonged wear. This means that breathing becomes more difficult for the wearer and the effectiveness of the filter is less certain. Check the manufacturer’s instructions for each specific mask. Many FFP3 respirators should be disposed of after a maximum of 8 hours.

FFP respirators: a good fit is essential

FFP respirators should be fit-tested to ensure an effective seal; if the seal is broken, air and droplets can enter around the edge of the mask. Formal fit-testing involves a health worker wearing the mask and performing different movements and breathing exercises while a strong, bitter substance is sprayed close to their face inside a hood; if they can taste the substance without the mask, but not with it, it fits. If this means of testing is not available, visually inspect that the mask fits snugly to the contours of the face. Observe the wearer breathing in and out to check that the movement in the shape of the mask is consistent with the breathing pattern, i.e., that the front of the mask depresses as they inhale and re-shapes as they exhale. Adjust the general fit and nose-pinching strip accordingly. One mask may not effectively fit all face shapes; ideally, each hospital should have multiple types available to increase the chance of finding one for everyone.

Facial hair

A good seal is impossible if there is facial hair (including stubble) under the edge of the mask. Some styles of beard or moustache are compatible with a good fit if they do not cross the edge of the mask. If, for cultural reasons, a person cannot remove facial hair that crosses the edge of the mask, it is recommended that their duties are temporarily reassigned. If this is not possible, an alternative option would be to wear a full head respirator.

Gloves

Use of gloves is indicated during all patient-care activities that may involve exposure to blood and all other body fluids (including contact with mucous membrane and non-intact skin), during contact precautions and outbreak situations.

COVID-19 is an outbreak situation, so glove use is advised for all patient care activities, even in situations ordinarily considered ‘very low risk’ and for which gloves would not usually be indicated.

Figure 3 WHO guidance – How to put gloves on Take a glove from its original box, touching only a small area at the top edge of the cuff (a),corresponding to the wrist, and put it on (b). Use your bare hand to take a second glove from the box, touching only the top edge (c). To avoid touching the skin of the forearm with the gloved hand, hook the outside of the second glove over the fingers of your gloved hand (d) when putting it on.
Black and white drawings of how to take gloves off
Figure 3 WHO guidance – How to take gloves off Without touching your forearm, pinch one glove at the wrist (e) and removeit by peeling it away from the hand, allowing the glove to turn inside out as you do so. While still holding this glove, slide the fingers of your bare hand inside the remaining glove (f) and roll it off your hand and over the first glove (g). Discard both gloves in the correct bin and wash your hands.

Gloves do not provide complete protection

Gloves are only effective when used appropriately (Figure 3) and in combination with good hand hygiene before use and after removal. Prolonged use without adequate hand hygiene may contribute to infection transmission.

It is vital to remove and replace gloves between each patient. Medical gloves are single-use items; decontamination and reprocessing are not recommended and should be avoided, even where glove supply is limited, because there is no standardised, validated and affordable procedure for safe glove reprocessing.

Thick rubber gloves, such as those used when cleaning, should be disinfected between clinical spaces.12 For the latest guidance, visit bit.ly/WHOgloves

Eye protection

In many settings, health care workers are encouraged to wear eye protection (goggles or visors/face shields) when in close contact with patients. Eye protection can be re-used.13 After each session, clean goggles and face shields using detergent, then using hospital disinfectant. Finish by wiping with water or 70% ethanol to remove any residues.

Donning and doffing PPE

Just as important as which PPE is worn, is how to put on (don) and take off (doff) PPE safely.

Donning

Figure 5 shows the order suggested by WHO for donning PPE to avoid contact or droplet transmission:

  1. Perform hand hygiene
  2. Put on the gown (or apron, if fluid-resistant gowns are not available)
  3. Put on the surgical or respirator mask
  4. Put on eye protection (goggles or visor/face shield)
  5. Put on gloves. Ensure the gloves are placed over the cuff of the gloves.

Doffing

Figure 6 shows the order suggested by WHO for taking off PPE worn for contact and droplet precautions.

  1. Remove gloves. Avoid touching the outside of the glove. Instead, start at the cuff and peel the glove off, so it is inside-out when you are finished.
  2. Remove the gown (or apron, if fluid-resistant gowns are not available)
  3. Perform hand hygiene
  4. Remove eye protection (goggles or face shield)
  5. Remove the mask (or respirator). Ensure that you touch only the straps, not the mask itself.
  6. Perform hand hygiene.

Note: Hand hygiene must be performed twice: once after removing the gloves and gown, and once when everything else has been removed.

Pay extra attention to avoid contaminating yourself when removing PPE at the end of a session, e.g., by touching the outside of a face visor and then touching your face. If your hands become contaminated at any point during putting on or taking off PPE, wash them immediately. Always wash hands immediately after taking off all PPE. In a high-risk setting, where there is a risk of airborne transmission, a PPE ‘buddy’ should help with putting on PPE, for example, by tying the back of your gown.

Poster showing how to put PPE on correctly
Figure 5 How to don PPE for contact and droplet precautions © World Health Organization
Poster showing how to remove PPE correctly
Figure 6 How to don PPE for contact and droplet precautions © World Health Organization

Put used PPE in the correct waste or laundry collection receptacle after removal to ensure safe decontamination and disposal.

Making PPE work in your setting

Depending on the local setting and supplies, choose the best available combinations of PPE for both low- and high-risk exposure and develop a strategy or protocol for decontaminating and re-using specific PPE items if needed. All relevant staff members must be made aware of the chosen strategy and taught how to carry it out appropriately. Using the best PPE available in each setting is extremely important in reducing COVID-19 transmission.

Wearing PPE, particularly face masks, can create an additional barrier in patient care, as patients may find it difficult to engage with health care workers if they cannot see their faces. It can also become much more difficult to hear people when they are wearing masks. To assist communication between health care workers, some hospitals are using hand signals to indicate ‘up’, ‘down’, ‘good’, ‘there’s a problem’, etc. across a noisy ward. It is worth considering implementing this in your unit; if you do, make sure that all staff members know what the different signals mean.

Wearing full PPE can be very uncomfortable, especially on hot days, and staff members should look out for each other and be wary if they start to feel faint and remember to take regular breaks. Hydrate before donning PPE in warm climates or warm health care environments.

As described, the reality of using PPE in a clinical setting can be very challenging, including changing equipment between patients and avoiding cross-contamination, especially if there are shortages of proper equipment. It is important to use PPE along with other infection control guidelines such as proper hand washing and waste disposal. We hope that applying these principles, in a common-sense manner, will help to keep health workers and patients safe.

What if we’re running out of PPE?

There has been a global shortage of PPE during this pandemic. Many countries and districts have had to modify guidance depending on PPE availability. WHO and the Center for Disease Control (CDC) in the United States have offered helpful guidance on this.10,13,14

Good management of PPE supplies is essential to prevent shortages. This involves forecasting need and monitoring use and distribution. It is important to emphasise that, where possible, PPE of verified quality should always be used, via countries’ official registered sources.15 Where alternative sources are required, we must ensure that new supply chains, which may have been developed very quickly, do not involve exploitation of labourers.

When PPE is in short supply, follow the measures set out in your local or national guidelines. Practices that would be unacceptable in ‘normal’ circumstances have had to be considered due to current extenuating circumstances resulting from this pandemic.

Some PPE can be disinfected and re-used. These include goggles, face shields, fabric gowns or scrubs that can be washed and re-used.

In the current exceptional pandemic crisis, reprocessing of disposable PPE is an evolving area where research and development is ongoing and urgently needed. Reuse of any item without a reprocessing/decontamination process is considered inadequate and unsafe. Normally, cleaning before disinfection and sterilisation is required for any reprocessing methods, which is not possible for masks and respirators.

Methods for reprocessing masks or respirators are not well standardised or established but possible means of decontamination are under investigation for extreme shortages.16

  • Prioritise who gets which PPE, e.g., prioritise face masks for health care providers rather than patients, or prioritise them for use only in close contact and while carrying out care activities which involve splash or spray. Prioritise glove use for healthcare workers engaged with high risk procedures or patients. If glove supplies are extremely limited, hand hygiene alone may suffice when performing very low risk procedures for which gloves are not normally indicated, for e.g. taking a patient’s blood pressure, temperature or pulse – refer to WHO guidelines.12
  • Extend the use of PPE for longer than is normally recommended. E.g., for FFP3 respirators, sessional use can be considered.

NOTE: Because advice is regularly being supplemented and revised, please refer to the WHO, RCOphth and AAO websites mentioned in this article for the most up-to-date recommendations.

References

1 World Health Organization. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations. WHO 2020.

2 van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and surface stability of SARS- CoV-2 as compared with SARS-CoV-1. N Engl J Med 2020; 382:1564-1567. doi:10.1056/ NEJMc2004973.

3 Xia J, Tong J, Liu M, Shen Y, Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol 2020; 92(6):589-564.

4 Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect 2020;104(3):246-51.

5 Chodosh J, Holland GN, Yeh S. Special considerations for ophthalmic surgery during the COVID-19 pandemic. AAO 2020. Available at: bit.ly/AAOrisk

6 Lai THT, Tang EWH, Chau SKY, Fung KSC, Li KKW. Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: an experience from Hong Kong. Graefes Arch Clin Exp Ophthalmol 2020; 258(5):1049-55.

7 Italian Ophthalmological Society. Directions for the protection of patients, ophthalmologists, health and administrative personnel. IOS 2020.

8 Spanish Society of Ophthalmology. Recommendations for the care of ophthalmology patients in relation to the COVID-19 emergency. SSO 2020.

9 Royal College of Ophthalmologists. PPE and staff protection requirements for ophthalmology. RCOphth 2020.

10 World Health Organization. Rational use of personal protective equipment for coronavirus disease (COVID-19) and considerations during extreme shortages. WHO 2020. Available at: bit.ly/ PPEguideCOV19

11 Davies A, Thompson KA, Giri K, Kafatos G, Walker J, Bennett A. Testing the efficacy of homemade masks: would they protect in an influenza pandemic? Disaster Med Public Health Prep 2013; 7(4):413-8.

12 World Health Organization. Glove use information leaflet. WHO 2009. bit.ly/WHOgloves

13 Centers for Disease Control and Prevention. Strategies for optimizing the supply of eye protection. CDC 2020.

14 Centers for Disease Control and Prevention. Strategies to optimize the supply of PPE and equipment. CDC 2020. Available at: bit.ly/CDCguidePPE

15 Mariotti S, Cieza A, Holland P. Eye Health and COVID-19 – A webinar. Online: IAPB 2020.

16 Centers for Disease Control and Prevention. Decontamination and reuse of filtering facepiece respirators. CDC 2020.